{"database":"iProX","file_versions":[],"scores":null,"additional":{"omics_type":["Proteomics"],"submitter":["Min Zhao"],"species":["Rattus Rattus"],"full_dataset_link":["http://www.iprox.org/page/project.html?id=IPX0011841000"],"submitter_email":["zmin13@hbtcm.edu.cn"],"submitter_affiliation":["Basic Medical Division, Hubei University of Chinese Medicine"],"sample_protocol":[""],"repository":["iProX"],"data_protocol":[""],"description_synonyms":["rm62, CG10279, CDF, Rat, Ideal, Laboratory, Silencer factor B, RM62, Norway Rat, l(3)s5196, protein, Dmp68, l(3)rG338, One-Person Households, Biological Assay, Dmlip1, Average Family Sizes, Norway Rats, EP(X)0356, protein polypeptide chains, rat, POF, Household Heads, Liver activator protein, Head of Household, Tongue Diagnoses, High-Throughput Screening, Ideal Family Size, High-Throughput Biological Assays, High-Throughput Chemical Assays, AGAMOUS-like 61, Norway rat, Analysis, C|EBP-related protein 2, protein aggregate, prevention and control, dwp, LIP1, DiA, Family and Household, Mass Spectrum Analysis, Lips, l(2)k07135, reference sample, ATP-dependent proteolysis, Analyses, poi, Expected Family Sizes, Tissue, LiP, Premature Ovarian Failure, Chinese Medicine, prevention., proteins, DIASP, dmP68, Protein Degradation, Family Life Survey, DIA, Dia, Laboratory Rat, cc, preventive measures, 4-(4-dihexadecylaminostyryl)N-methylpyridium iodide, Family Life, Completed Family Sizes, Average, Philtrum, Tongue Assessment, CP, Chung I, 38E.16, lips, LIP, Lip, C/EBPbeta, Screening Assay, One-Person, Primary ovarian insufficiency, Traditional, Desired, Generations, ATX, Degradations, preventive therapy, Traditional Medicine, DmRH8, premature ovarian failure, CRP2, EG:171D11.3, oos, lip, Rattus, hypergonadotrophic ovarian failure, High Throughput Chemical Assays, premature menopause, Spectrum Analysis, LIP1Dm, Household and Family, Spectroscopy, Expected, premature ovarian insufficiency, ms(2)04138, Traditional Tongue Diagnoses, Desmoplastic infantile astrocytoma, Mus norvegicus, l(3)01086, Premature ovarian failure, Household, Rattus norwegicus, CpepE, Digestion, Completed Family Size, High-Throughput Chemical, Primary Ovarian Insufficiency, Ideal Family Sizes, l(3)j3D2, Tongue Diagnosis, l(3)j3D5, Couples, Early menopause, CypD, High-Throughput Biological Assay, Zhong Yi Xue, POF2, Protein Digestions, F27C12_24, Family Demographies, F27C12.24, Spectrometry, DLiprin-alpha, NF-IL6, rats, Nfil6, Hsueh, Interleukin-6-dependent-binding protein, lip-alpha, Traditional Chinese Medicine, DIANA, hypergonadotropic hypogonadism (female), Household Head, 61E3.4, Liver-enriched inhibitory protein, Dliprin-alpha, DmelCG4122, Desired Family Sizes, Menopause praecox, norvegicus, primary female hypogonadism, Peptidomics, Degradation, Liver-enriched transcriptional activator, number, Gene, Family Sizes, DmelCG10279, Spectrum Analyses, Traditional Tongue Assessment, protein-containing complex, presence, labia oris, TCF-5, Rattus sp. strain Wistar, LIP.1, dLip1, One Person Household, Rats, polypeptide chain, Transcription factor 5, High-Throughput Biological, DmelCG1768, High-Throughput Screening Assay, Gene Products, Mass, HILDA, Screening, Survey, p68, C|EBPbeta, Rattus rattiscus, CG7279, Traditional Tongue Diagnosis, slv, Mass Spectroscopy, CG11199, brown rat, Rattus norvegicus, Nuclear factor NF-IL6, High Throughput Screening Methods, Climacterium praecox, l(1)1Bd, Protein Degradations, NF-M, Family Size, hypergonadotropic hypogonadism, High Throughput Screening Assays, High-Throughput Screening Method, Households, Philtrums, SF-B, lpr, Traditional Tongue Assessments, High-Throughput, Chronic, CPD, DIA2, Chinese, Family, LAP, Desired Family Size, Family Characteristic, Controlled, Rattus norvegicus8, DmelCG7279, Controlling, protein complex, Screening Method, Desmoplastic astrocytoma of infancy, Proteins, Assay, High-Throughput Screenings, One-Person Household, Family Demography, CG1768, Expected Family Size, Protein Digestion, DRF2, Digestions, count in organism, MS, native protein, natural protein, Proteolyses, High Throughput Biological Assays, Laboratory Rats, Protein, MLPLI, Premature menopause, High-Throughput Chemical Assay, CG4122, Dias, 4136, female hypergonadotropic hypogonadism, CG18503, Average Family Size, Mass Spectrum Analyses, Chemical Assay, Mass Spectrum, Demography, High Throughput Screening, DmelCG11199, lip1, prophylaxis, High-Throughput Screening Methods, Family Life Surveys, DLiprin, Protein Gene Products, Gene Proteins, Chinese Traditional Medicine, Hypergonadotropic amenorrhea, C|EBP beta, control, IL-6DBP, CG32818, Norway, Chung I Hsueh, Completed, Gunn rats"],"name_synonyms":["ovarian failure, Complement Proteins, ovarian dysfunction, Complement, ovarian hypofunction, Protein, Proteins, anxiety, ovarian insufficiency, Complement System, Hemolytic, Hemolytic Complement, Complement Protein, clotting."],"additional_accession":[]},"is_claimable":false,"name":"Mechanism of Zuogui Wan in ameliorating chronic stress-induced intergenerational transmission of ovarian dysfunction via the complement and coagulation cascade pathway","description":"To systematically identify protein targets interacting with traditional Chinese medicine Zuogui Wan, limited proteolysis mass spectrometry (LiP-MS) was employed as a high-throughput screening platform. To investigate the molecular mechanisms underlying chronic unpredictable mild stress (CUMS)-induced Premature ovarian insufficiency (POI), we performed data-independent acquisition (DIA) quantitative proteomics on ovarian tissues from three generations of rats (Control vs. Model groups).","dates":{"publication":"Tue Apr 29 00:00:00 BST 2025"},"accession":"PXD063422","cross_references":{"TAXONOMY":["10117"]}}