{"database":"iProX","file_versions":[],"scores":null,"additional":{"omics_type":["Proteomics"],"submitter":["Zhengxuan Jiang"],"species":["Rattus Rattus"],"full_dataset_link":["http://www.iprox.org/page/project.html?id=IPX0013896000"],"submitter_email":["jiangzhengxuan@ahmu.edu.cn"],"submitter_affiliation":["The Second Affiliated Hospital of Anhui Medical University"],"sample_protocol":[""],"repository":["iProX"],"data_protocol":[""],"additional_accession":[]},"is_claimable":false,"name":"This study presents a global lactylome profiling of retinal tissues from diabetic retinopathy (DR) and control rats, revealing significant alterations in lysine lactylation that provide novel insights into the pathogenesis of DR","description":"Our comprehensive lactylome analysis delineates a compelling association between protein lactylation and diabetic retinopathy (DR). In the retinas of DR rats, we observed a marked imbalance in lactylation, with 55 sites on 49 proteins being significantly upregulated and 69 sites on 57 proteins downregulated compared to controls, highlighting the potential role of lactylation-driven pathways in DR pathology.","dates":{"publication":"Tue Oct 21 00:00:00 GMT+01:00 2025"},"accession":"PXD069762","cross_references":{"TAXONOMY":["10117"]}}