iProXProteomicsYuxin YangCapra Hircushttp://www.iprox.org/page/project.html?id=IPX0014071000yangyuxin2002@126.comNorthwest Agriculture and Forestry UniversityiProXfalseThymol and carvacrol alleviate intestinal inflammation in lambs via the Romboutsia maritimum-benzyl cinnamate-GALNT7/MUC2 axisDietary supplementation with thymol and carvacrol (CAT) effectively mitigated intestinal inflammation in diarrheic lambs. Multi-omics integrative analyses demonstrated that CAT selectively enriched Romboutsia maritimum, whose metabolic activity led to the production of benzyl cinnamate—a microbial metabolite with potent anti-inflammatory properties. Mechanistically, benzyl cinnamate activated the host glycosyltransferase GALNT7 to upregulate MUC2 expression, thereby promoting mucosal barrier restoration and counteracting E. coli (O157:H7)–induced intestinal injury.Mon Nov 03 00:00:00 GMT 2025PXD0702129925