{"database":"iProX","file_versions":[],"scores":null,"additional":{"omics_type":["Proteomics"],"submitter":["Hualun Liang"],"species":["Mus Musculus"],"full_dataset_link":["http://www.iprox.org/page/project.html?id=IPX0014332000"],"submitter_email":["13412984423@163.com"],"submitter_affiliation":["The Second Affiliated Hospital of Guangzhou University of Chinese Medicine"],"sample_protocol":[""],"repository":["iProX"],"data_protocol":[""],"pubmed_abstract":["The sigma-2 receptor has been identified as a marker of abnormal tumor proliferation. Novel sigma-2 small molecule probes have been developed to assist in localizing tumor sites, tracking in vivo tumor cell proliferation and migration, and facilitating cancer diagnosis and treatment. A series of tetrahydroisoquinoline- and polysubstituted benzylamine-based sigma-2 small molecule probes were synthesized, and compounds 6-8 were found to exhibit moderate to high affinity and selectivity for sigma-2 receptors, with Ki values ranging from 7.8 to 53.2 nM. Functional analysis confirmed that the three active compounds act as sigma-2 receptor antagonists. Lower cytotoxicity was observed for compounds 6-8, with no significant or only weak cytotoxic effects detected in the MCF-7 cell line. In the tumor cell fluorescence imaging experiment, it could be clearly observed from the merged images that fluorescence was localized within MCF-7 cells, and target compounds 6-8 were able to enter target cells and exhibit obvious fluorescence. Among them, the fluorescence of compound 6 was the most distinct."],"pubmed_title":["Synthesis and functional evaluation of tetrahydroisoquinoline and polysubstituted benzylamine derivatives as sigma-2 receptor-targeted small-molecule probes."],"pubmed_authors":["Chen Ai-Fang AF, Xie Xiao-Yang XY, Xu Wei-Shuai WS, Wang Ya-Xin YX, Liang Hua-Lun HL"],"additional_accession":[]},"is_claimable":false,"name":"Study on active components and pharmacology of Ganoderma lucidum","description":"By using the thermoproteomics method, proteins with significant differences in thermal stability were screened out in the HT22 cell line after administration of Ganoderma lucidum extract. Further mass spectrometry analysis was conducted to determine the categories of these proteins.","dates":{"publication":"Fri Nov 21 00:00:00 GMT 2025"},"accession":"PXD071098","cross_references":{"TAXONOMY":["10090"],"pubmed":["40953681"]}}