{"database":"iProX","file_versions":[],"scores":null,"additional":{"omics_type":["Proteomics"],"submitter":["Qiang Zuo"],"species":["Mus <genus>"],"full_dataset_link":["http://www.iprox.org/page/project.html?id=IPX0014923000"],"submitter_email":["nfyyzq@126.com"],"submitter_affiliation":["Nanfang Hospital, Southern Medical University"],"sample_protocol":[""],"repository":["iProX"],"data_protocol":[""],"pubmed_abstract":["Gastric cancer is one of the most prevalent cancers worldwide and is associated with a high mortality rate. Although immunotherapy has achieved some success for many tumor types, the limited response of gastric cancer to immunotherapy poses a challenge. Lactylation is a recently proposed post-translational modification derived from lactate that plays a key role in many physiological processes. In this study, we found that endoplasmic reticulum stress (ERS)-induced histone lactylation attenuated the immune response of dendritic cells (DC), decreased the ability of T cells to kill tumor cells, and enhanced tumor growth. Interestingly, ERS-induced H4K12 lactylation promoted the expression of PDIA6 in DC, leading to weakened immune activity of DC and decreased anti-tumor ability of T cells, thereby promoting gastric cancer immune evasion. Collectively, our work provides new insights into how ERS-induced lactylation modification attenuates the stability of DC to drive immune escape in gastric cancer and provides a promising biomarker for the efficacy of immunotherapy in gastric cancer."],"pubmed_title":["Endoplasmic reticulum stress-induced histone lactylation mediating immune escape of gastric cancer via PDIA6 overexpression in dendritic cells."],"pubmed_authors":["Tu Chengshu C, Wu Ziqing Z, Zhong Xuxian X, Yang Shengnan S, Chen Xi X, Li Simin S, Xu Youqin Y, Zuo Qiang Q"],"additional_accession":[]},"is_claimable":false,"name":"Endoplasmic Reticulum Stress-induced Histone Lactylation Mediating Immune Escape of Gastric Cancer via PDIA6 Overexpression in Dendritic Cells","description":"First, cell histones were extracted using a histone extraction kit (Solarbio, China), followed by the preparation of protein samples. Protein samples were then isolated by SDS-PAGE and stained with Richfast SDS-PAGE Staining Buffer (Prosperich, China). The colloids were cut for MS analysis to determine the location of the lactylation group.","dates":{"publication":"Tue Dec 30 00:00:00 GMT 2025"},"accession":"PXD072553","cross_references":{"TAXONOMY":["10088"],"pubmed":["41896533"]}}