{"database":"iProX","file_versions":[],"scores":null,"additional":{"omics_type":["Proteomics"],"submitter":["Zhenya Shen"],"species":["Rattus Norvegicus"],"full_dataset_link":["http://www.iprox.org/page/project.html?id=IPX0015090000"],"submitter_email":["uuzyshen@aliyun.com"],"submitter_affiliation":["First Affiliated Hospital, Soochow University"],"sample_protocol":[""],"repository":["iProX"],"data_protocol":[""],"additional_accession":[]},"is_claimable":false,"name":"Proteomic Profiling of Plasma Extracellular Vesicles Reveals a Therapeutically Targetable Liver-Heart Axis in Cardiac Transplantation","description":"Extracellular vesicles (EVs)-mediated inter-organ communication represents a promising frontier in transplant immunology; however, its role in cardiac allograft rejection remains poorly characterized. We performed proteomic profiling of plasma-derived EVs in a rat heterotopic heart transplantation model. By comparing allogeneic and isogeneic graft recipients to sham-operated controls, we identified significant enrichment of hepatic-specific proteins in circulating EVs during acute rejection, with ATIII emerging as a top candidate.","dates":{"publication":"Sun Jan 11 00:00:00 GMT 2026"},"accession":"PXD072924","cross_references":{"TAXONOMY":["10116"]}}