iProXProteomicsZhenya ShenRattus Norvegicushttp://www.iprox.org/page/project.html?id=IPX0015090000uuzyshen@aliyun.comFirst Affiliated Hospital, Soochow UniversityiProXfalseProteomic Profiling of Plasma Extracellular Vesicles Reveals a Therapeutically Targetable Liver-Heart Axis in Cardiac TransplantationExtracellular vesicles (EVs)-mediated inter-organ communication represents a promising frontier in transplant immunology; however, its role in cardiac allograft rejection remains poorly characterized. We performed proteomic profiling of plasma-derived EVs in a rat heterotopic heart transplantation model. By comparing allogeneic and isogeneic graft recipients to sham-operated controls, we identified significant enrichment of hepatic-specific proteins in circulating EVs during acute rejection, with ATIII emerging as a top candidate.Sun Jan 11 00:00:00 GMT 2026PXD07292410116