iProXProteomicsJianjun LiHomo Sapienshttp://www.iprox.org/page/project.html?id=IPX0015172000jianjunli@tmmu.edu.cnSouthwest Hosipital, Third Military Medical UniversityiProXfalseSpatial proteomics based on laser capture micro-dissection (LCM) for investigating the impact of CD168+ TAM- coated tumor region (CCTR) on CD8+ T cells Function in colon cancer tissuesMultiplex immunofluorescence staining for CD11b, CD168, CD8, and Pan-CK was performed on three colon cancer specimens to identify CCTR regions. Subsequently, CD8+ T cells located at varying distances from the CCTR were subjected to single-cell resolution laser capture micro-dissection (LCM) and spatial proteomics analysis. These cells were categorized into three groups: the CCTR group (≤50 μm, n=393), the ad-CCTR group (>50 μm and ≤200 μm, n=375), and the non-CCTR group (>200 μm, n=383).Wed Jan 14 00:00:00 GMT 2026PXD0730519606