iProXProteomicsGuixue HouHomo Sapienshttp://www.iprox.org/page/project.html?id=IPX0015815000houguixue@genomics.cnUniversity of Chinese Academy of SciencesiProXfalseThalassemia carrier screening in pregnant women based on targeted quantification of hemoglobin subunits by LC-MS/MSThis study developed a novel thalassemia carrier screening method for pregnant women using LC-MS/MS-based targeted quantification of seven hemoglobin subunits. A machine learning model was trained on 1,726 subjects, achieving an AUC > 0.95. This approach provides a robust and physiologically adaptive strategy that outperforms traditional hematological indices in the pregnant population.Tue Feb 17 00:00:00 GMT 2026PXD0748359606