{"database":"iProX","file_versions":[],"scores":null,"additional":{"omics_type":["Proteomics"],"submitter":["Mian Wu"],"species":["Homo Sapiens"],"full_dataset_link":["http://www.iprox.org/page/project.html?id=IPX0014984000"],"submitter_email":["wumian@ustc.edu.cn"],"submitter_affiliation":["Zhengzhou University, Zhengzhou University People's Hospital, Translational Medicine Research Center"],"sample_protocol":[""],"repository":["iProX"],"data_protocol":[""],"additional_accession":[]},"is_claimable":false,"name":"A CHKA–PML autophagy checkpoint enables tumors to evade glutamine starvation","description":"CHKA phosphorylates PML at Tyr339 to promote its cytoplasmic localization; cytoplasmic PML then induces WIPI2 SUMOylation at Lys281/283, blocking HUWE1-mediated degradation. Stabilized WIPI2 enhances autophagic flux and supports tumor cell survival under metabolic stress.","dates":{"publication":"Tue Mar 03 00:00:00 GMT 2026"},"accession":"PXD075116","cross_references":{"TAXONOMY":["9606"]}}