iProXProteomicsMian WuHomo Sapienshttp://www.iprox.org/page/project.html?id=IPX0014984000wumian@ustc.edu.cnZhengzhou University, Zhengzhou University People's Hospital, Translational Medicine Research CenteriProXfalseA CHKA–PML autophagy checkpoint enables tumors to evade glutamine starvationCHKA phosphorylates PML at Tyr339 to promote its cytoplasmic localization; cytoplasmic PML then induces WIPI2 SUMOylation at Lys281/283, blocking HUWE1-mediated degradation. Stabilized WIPI2 enhances autophagic flux and supports tumor cell survival under metabolic stress.Tue Mar 03 00:00:00 GMT 2026PXD0751169606