{"database":"iProX","file_versions":[],"scores":null,"additional":{"omics_type":["Proteomics"],"submitter":["Xiang Li"],"species":["Homo Sapiens"],"full_dataset_link":["http://www.iprox.org/page/project.html?id=IPX0016125000"],"submitter_email":["lixiang199284@hubu.edu.cn"],"submitter_affiliation":["Hubei University"],"sample_protocol":[""],"repository":["iProX"],"data_protocol":[""],"additional_accession":[]},"is_claimable":false,"name":"Proteomic validation of cell death mechanisms of HDQ-mediated copper transporting","description":"Inspired by a bacterial SUF-system inhibitor, we integrated its core scaffold with copper-transporting 8-hydroxyquinoline moiety, yielding four derivatives (HDQ, HDQ-S, HDQ-Ph, and HDQ-Me). Functionally, HDQ-mediated copper loading triggers hallmark cuproptosis features, induces DNA damage, disrupts Fe-S proteins,and collapses ATP production, creating synergistic lethality.","dates":{"publication":"Fri Mar 13 00:00:00 GMT 2026"},"accession":"PXD075646","cross_references":{"TAXONOMY":["9606"]}}