iProXProteomicsXiang LiHomo Sapienshttp://www.iprox.org/page/project.html?id=IPX0016125000lixiang199284@hubu.edu.cnHubei UniversityiProXfalseProteomic validation of cell death mechanisms of HDQ-mediated copper transportingInspired by a bacterial SUF-system inhibitor, we integrated its core scaffold with copper-transporting 8-hydroxyquinoline moiety, yielding four derivatives (HDQ, HDQ-S, HDQ-Ph, and HDQ-Me). Functionally, HDQ-mediated copper loading triggers hallmark cuproptosis features, induces DNA damage, disrupts Fe-S proteins,and collapses ATP production, creating synergistic lethality.Fri Mar 13 00:00:00 GMT 2026PXD0756469606