{"database":"iProX","file_versions":[],"scores":null,"additional":{"omics_type":["Proteomics"],"submitter":["Jinlai Wei"],"species":["Homo Sapiens"],"full_dataset_link":["http://www.iprox.org/page/project.html?id=IPX0016155000"],"submitter_email":["weilai03109@163.com"],"submitter_affiliation":["the First Affiliated Hospital of Chongqing Medical University"],"sample_protocol":[""],"repository":["iProX"],"data_protocol":[""],"additional_accession":[]},"is_claimable":false,"name":"Usnic acid target CRYAB phosphorylation to induce ferroptosis","description":"This study elucidates the critical role of CRYAB phosphorylation in driving the progression of liver metastasis in colorectal cancer, and validates that usnic acid exerts anti-metastatic activity by modulating this post-translational modification. Mechanistically, in addition to its established pro-apoptotic function, usnic acid triggers ferroptosis via suppressing CRYAB phosphorylation at the S59 site. These results construct a mechanistic basis for usnic acid as a promising therapeutic candidate against metastatic colorectal cancer, underscoring the translational potential of targeting CRYAB phosphorylation and ferroptosis for the clinical intervention of colorectal cancer liver metastases.","dates":{"publication":"Tue Mar 17 00:00:00 GMT 2026"},"accession":"PXD075743","cross_references":{"TAXONOMY":["9606"]}}