{"database":"iProX","file_versions":[],"scores":null,"additional":{"omics_type":["Proteomics"],"submitter":["Jinlai Wei"],"species":["Homo Sapiens"],"full_dataset_link":["http://www.iprox.org/page/project.html?id=IPX0016241000"],"submitter_email":["weilai03109@163.com"],"submitter_affiliation":["the First Affiliated Hospital of Chongqing Medical University"],"sample_protocol":[""],"repository":["iProX"],"data_protocol":[""],"additional_accession":[]},"is_claimable":false,"name":"Usnic Acid Inhibits Colorectal Cancer Liver Metastasis by Targeting CRYAB Phosphorylation and Inducing Ferroptosis","description":"Here we report that CRYAB phosphorylation serves as a key driver of colorectal cancer liver metastatic progression, and establish usnic acid as an anti-metastatic compound that functions by targeting this post-translational modification. Mechanistically, beyond its canonical pro-apoptotic activity, usnic acid induces ferroptosis through the selective inhibition of CRYAB phosphorylation at serine 59. These findings provide a mechanistic foundation for the development of usnic acid as a potential therapeutic agent for metastatic colorectal cancer, and emphasize the clinical potential of targeting CRYAB phosphorylation and ferroptosis in the management of colorectal cancer liver metastases.","dates":{"publication":"Wed Mar 18 00:00:00 GMT 2026"},"accession":"PXD075824","cross_references":{"TAXONOMY":["9606"]}}