iProXProteomicsJinlai WeiHomo Sapienshttp://www.iprox.org/page/project.html?id=IPX0016241000weilai03109@163.comthe First Affiliated Hospital of Chongqing Medical UniversityiProXfalseUsnic Acid Inhibits Colorectal Cancer Liver Metastasis by Targeting CRYAB Phosphorylation and Inducing FerroptosisHere we report that CRYAB phosphorylation serves as a key driver of colorectal cancer liver metastatic progression, and establish usnic acid as an anti-metastatic compound that functions by targeting this post-translational modification. Mechanistically, beyond its canonical pro-apoptotic activity, usnic acid induces ferroptosis through the selective inhibition of CRYAB phosphorylation at serine 59. These findings provide a mechanistic foundation for the development of usnic acid as a potential therapeutic agent for metastatic colorectal cancer, and emphasize the clinical potential of targeting CRYAB phosphorylation and ferroptosis in the management of colorectal cancer liver metastases.Wed Mar 18 00:00:00 GMT 2026PXD0758249606