{"database":"iProX","file_versions":[],"scores":null,"additional":{"omics_type":["Proteomics"],"submitter":["Hungchun Chang"],"species":["Mus Musculus"],"full_dataset_link":["http://www.iprox.org/page/project.html?id=IPX0016265000"],"submitter_email":["hcchang@lglab.ac.cn"],"submitter_affiliation":["Lingang Laboratory"],"sample_protocol":[""],"repository":["iProX"],"data_protocol":[""],"additional_accession":[]},"is_claimable":false,"name":"Excitatory neurons SIRT6 mediates chronic stress‑induced depression in mice","description":"We used acetyl-lysine antibody-based affinity enrichment followed by mass spectrometry to identify acetylation changes caused by SIRT6 overexpression. We co-overexpressed Flag-OVOL2 and pCMV-SIRT6 in N2a cells. At 96 h after transfection, we treated cells with TSA for 12 h, collected proteins and digested proteins into peptides, enriched acetylated peptides using an anti-acetyl-lysine antibody, and then performed LC-MS/MS.","dates":{"publication":"Fri Mar 20 00:00:00 GMT 2026"},"accession":"PXD075918","cross_references":{"TAXONOMY":["10090"]}}