{"database":"iProX","file_versions":[],"scores":null,"additional":{"omics_type":["Proteomics"],"submitter":["Jiajia Lu"],"species":["Mus Musculus"],"full_dataset_link":["http://www.iprox.org/page/project.html?id=IPX0016521000"],"submitter_email":["lujiajia@smmu.edu.cn"],"submitter_affiliation":["Shanghai Changzheng Hospital"],"sample_protocol":[""],"repository":["iProX"],"data_protocol":[""],"additional_accession":[]},"is_claimable":false,"name":"Based on multi-omics, revealing the key role of MOESIN lactic acidification-driven TGF-β signaling axis in improving diabetic osteoporosis through gut microbiota","description":"Diabetic osteoporosis (DOP), as a typical representative of metabolic-immune cross-talk imbalance, has an unclear pathogenesis and lacks effective targeted intervention methods. This study aims to systematically analyze the molecular mechanism by which fecal microbiota transplantation (FMT) activates the TGF-β signaling axis through MOESIN lactic acid modification, reshapes the Treg/Th17 immune balance, and improves the pathological process of DOP based on multi-omics integrated analysis","dates":{"publication":"Fri Apr 03 00:00:00 BST 2026"},"accession":"PXD076650","cross_references":{"TAXONOMY":["10090"]}}