iProXProteomicsJiajia LuMus Musculushttp://www.iprox.org/page/project.html?id=IPX0016521000lujiajia@smmu.edu.cnShanghai Changzheng HospitaliProXfalseBased on multi-omics, revealing the key role of MOESIN lactic acidification-driven TGF-β signaling axis in improving diabetic osteoporosis through gut microbiotaDiabetic osteoporosis (DOP), as a typical representative of metabolic-immune cross-talk imbalance, has an unclear pathogenesis and lacks effective targeted intervention methods. This study aims to systematically analyze the molecular mechanism by which fecal microbiota transplantation (FMT) activates the TGF-β signaling axis through MOESIN lactic acid modification, reshapes the Treg/Th17 immune balance, and improves the pathological process of DOP based on multi-omics integrated analysisFri Apr 03 00:00:00 BST 2026PXD07665010090