{"database":"iProX","file_versions":[],"scores":null,"additional":{"omics_type":["Proteomics"],"submitter":["Jianqin Liang"],"species":["Rattus Rattus"],"full_dataset_link":["http://www.iprox.org/page/project.html?id=IPX0016740000"],"submitter_email":["000298@gxtcmu.edu.cn"],"submitter_affiliation":["Guangxi University of Chinese Medicine"],"sample_protocol":[""],"repository":["iProX"],"data_protocol":[""],"additional_accession":[]},"is_claimable":false,"name":"Protective effects of Sifangteng on rheumatoid arthritis in rats via regulation of the STAT3-MMPs axis","description":"This study systematically evaluated the therapeutic effects of the traditional Yao medicine Sifangteng formula (SFTF) on rheumatoid arthritis (RA) using a collagen-induced arthritis (CIA) rat model. Multi-omics approaches, including widely targeted metabolomics, TMT-based quantitative proteomics, network pharmacology, WGCNA, and single-cell RNA sequencing analysis, were integrated to identify active components and key molecular targets. The results demonstrated that SFTF attenuates synovial inflammation and joint destruction by regulating the STAT3-MMPs axis. Key bioactive compounds such as quercitrin, hesperidin, and luteolin-7,3'-di-O-glucoside were identified and validated in vitro. This study provides a mechanistic basis for the traditional use of Sifangteng in RA treatment.","dates":{"publication":"Mon Apr 20 00:00:00 BST 2026"},"accession":"PXD077368","cross_references":{"TAXONOMY":["10117"]}}