{"database":"iProX","file_versions":[],"scores":null,"additional":{"omics_type":["Proteomics"],"submitter":["Yong Gao"],"species":["Mus Musculus"],"full_dataset_link":["http://www.iprox.org/page/project.html?id=IPX0016886000"],"submitter_email":["drgaoyong@tongji.edu.cn"],"submitter_affiliation":["Shanghai East Hospital"],"sample_protocol":[""],"repository":["iProX"],"data_protocol":[""],"additional_accession":[]},"is_claimable":false,"name":"CRLF1 contributes to acquired resistance to immune checkpoint blockade in mismatch repair-deficient colorectal cancer","description":"Immune checkpoint blockade (ICB) has greatly improved survival for mismatch repair-deficient metastatic colorectal cancer (dMMR/dCRC) patients, yet 40%–60% either fail to respond or develop acquired resistance (AR). This study established an anti-PD-1-resistant dCRC model and identified cytokine receptor-like factor 1 (CRLF1) as a key mediator of AR, whose upregulation impairs CD8+ T-cell anti-tumor immunity.","dates":{"publication":"Mon Apr 27 00:00:00 BST 2026"},"accession":"PXD077703","cross_references":{"TAXONOMY":["10090"]}}