iProXProteomicsYong GaoMus Musculushttp://www.iprox.org/page/project.html?id=IPX0016886000drgaoyong@tongji.edu.cnShanghai East HospitaliProXfalseCRLF1 contributes to acquired resistance to immune checkpoint blockade in mismatch repair-deficient colorectal cancerImmune checkpoint blockade (ICB) has greatly improved survival for mismatch repair-deficient metastatic colorectal cancer (dMMR/dCRC) patients, yet 40%–60% either fail to respond or develop acquired resistance (AR). This study established an anti-PD-1-resistant dCRC model and identified cytokine receptor-like factor 1 (CRLF1) as a key mediator of AR, whose upregulation impairs CD8+ T-cell anti-tumor immunity.Mon Apr 27 00:00:00 GMT+01:00 2026PXD07770310090