{"database":"iProX","file_versions":[],"scores":null,"additional":{"omics_type":["Proteomics"],"submitter":["Zhihua Wang"],"species":["Mus Musculus"],"full_dataset_link":["http://www.iprox.org/page/project.html?id=IPX0017093000"],"submitter_email":["wangzh@ustc.edu.cn"],"submitter_affiliation":["University of Science and Technology of China"],"sample_protocol":[""],"repository":["iProX"],"data_protocol":[""],"additional_accession":[]},"is_claimable":false,"name":"Liver proteomic profiling of mice with hepatic Ier2 overexpression following acetaminophen (APAP) administration","description":"This study aims to investigate the role of IER2 in acetaminophen (APAP)- induced liver injury. Male C57BL/6J mice were randomized to receive a single tail vein injection of either AAV8-GFP or AAV8-Ier2. Mice were fasted overnight for 14 hours followed by intraperitoneal administration of APAP (500 mg/kg). Animals were sacrificed 8 hours post-APAP challenge, and liver tissues were collected for proteomic profiling. This study aims to characterize the proteomic changes associated with IER2 overexpression during APAP hepatotoxicity, thereby establishing a foundation for subsequent mechanistic investigations.","dates":{"publication":"Sun May 10 00:00:00 BST 2026"},"accession":"PXD078216","cross_references":{"TAXONOMY":["10090"]}}