iProXProteomicsZhihua WangMus Musculushttp://www.iprox.org/page/project.html?id=IPX0017093000wangzh@ustc.edu.cnUniversity of Science and Technology of ChinaiProXfalseLiver proteomic profiling of mice with hepatic Ier2 overexpression following acetaminophen (APAP) administrationThis study aims to investigate the role of IER2 in acetaminophen (APAP)- induced liver injury. Male C57BL/6J mice were randomized to receive a single tail vein injection of either AAV8-GFP or AAV8-Ier2. Mice were fasted overnight for 14 hours followed by intraperitoneal administration of APAP (500 mg/kg). Animals were sacrificed 8 hours post-APAP challenge, and liver tissues were collected for proteomic profiling. This study aims to characterize the proteomic changes associated with IER2 overexpression during APAP hepatotoxicity, thereby establishing a foundation for subsequent mechanistic investigations.Sun May 10 00:00:00 BST 2026PXD07821610090