{"database":"iProX","file_versions":[],"scores":null,"additional":{"omics_type":["Proteomics"],"submitter":["Pei Zhang"],"species":["Homo Sapiens"],"full_dataset_link":["http://www.iprox.org/page/project.html?id=IPX0017329000"],"submitter_email":["zhangpei@ahmu.edu.cn"],"submitter_affiliation":["Department of Nephrology, The First Affiliated Hospital of Anhui Medical University"],"sample_protocol":[""],"repository":["iProX"],"data_protocol":[""],"additional_accession":[]},"is_claimable":false,"name":"Proteomic profiling of extracellular vesicles (EVs) isolated from peritoneal dialysis effluent (PDE) of short-term (SPD) and long-term (LPD) PD patients","description":"This project presents proteomic profiling of extracellular vesicles (EVs) isolated from peritoneal dialysis effluent (PDE) of short-term (SPD) and long-term (LPD) PD patients. We identified 536 differentially expressed proteins (DEPs), revealing an immune-enriched EV signature in LPD. CSF1 was prioritized as a key profibrotic mediator, validated in vitro and in vivo to drive macrophage-to-myofibroblast transition (MMT) via AKT signaling. Clinical data (n=84) links dialysate CSF1 to PF progression. This dataset provides mechanistic insights and biomarker candidates for PD-related fibrosis.","dates":{"publication":"Sat May 23 00:00:00 BST 2026"},"accession":"PXD078788","cross_references":{"TAXONOMY":["9606"]}}