iProXProteomicsPei ZhangHomo Sapienshttp://www.iprox.org/page/project.html?id=IPX0017329000zhangpei@ahmu.edu.cnDepartment of Nephrology, The First Affiliated Hospital of Anhui Medical UniversityiProXfalseProteomic profiling of extracellular vesicles (EVs) isolated from peritoneal dialysis effluent (PDE) of short-term (SPD) and long-term (LPD) PD patientsThis project presents proteomic profiling of extracellular vesicles (EVs) isolated from peritoneal dialysis effluent (PDE) of short-term (SPD) and long-term (LPD) PD patients. We identified 536 differentially expressed proteins (DEPs), revealing an immune-enriched EV signature in LPD. CSF1 was prioritized as a key profibrotic mediator, validated in vitro and in vivo to drive macrophage-to-myofibroblast transition (MMT) via AKT signaling. Clinical data (n=84) links dialysate CSF1 to PF progression. This dataset provides mechanistic insights and biomarker candidates for PD-related fibrosis.Sat May 23 00:00:00 BST 2026PXD0787889606