{"database":"iProX","file_versions":[],"scores":null,"additional":{"omics_type":["Proteomics"],"submitter":["Xiaoguang Lei"],"species":["Homo Sapiens"],"full_dataset_link":["http://www.iprox.org/page/project.html?id=IPX0017246000"],"submitter_email":["xglei@pku.edu.cn"],"submitter_affiliation":["Peking University"],"sample_protocol":[""],"repository":["iProX"],"data_protocol":[""],"additional_accession":[]},"is_claimable":false,"name":"Development of Dual-Mechanism Small-Molecule Degraders for Treatment of Advanced Prostate Cancer","description":"In this study, we present the discovery, mechanistic insights, and preclinical validation of a potent, selective small-molecule drug candidate with dual PROTAC and molecular glue mechanisms that target human androgen receptors. This drug lead shows remarkable therapeutic potential on various drug-resistant prostate cancers.","dates":{"publication":"Sat May 23 00:00:00 BST 2026"},"accession":"PXD078789","cross_references":{"TAXONOMY":["9606"]}}