iProXProteomicsXiaoguang LeiHomo Sapienshttp://www.iprox.org/page/project.html?id=IPX0017246000xglei@pku.edu.cnPeking UniversityiProXfalseDevelopment of Dual-Mechanism Small-Molecule Degraders for Treatment of Advanced Prostate CancerIn this study, we present the discovery, mechanistic insights, and preclinical validation of a potent, selective small-molecule drug candidate with dual PROTAC and molecular glue mechanisms that target human androgen receptors. This drug lead shows remarkable therapeutic potential on various drug-resistant prostate cancers.Sat May 23 00:00:00 BST 2026PXD0787899606