iProXProteomicsJinlong WangStreptomyces Microflavushttp://www.iprox.org/page/project.html?id=IPX0017596000jinlongwang@ucas.ac.cnHangzhou Institute for Advanced Study, University of Chinese Academy of SciencesiProXfalseThe profiling of bile acid-inducing proteins in Streptomyces microflavusTo further investigate the potential functions of Streptomyces in the gut, the bile acid-induction experiment was conducted utilizing mass spectrometry for identification. Bile acids (BAs), crucial primary metabolites of cholesterol metabolism, play a vital role in lipid digestion and absorption, enterohepatic circulation, and metabolic regulation. Notably, elevated intestinal bile acid levels are observed during high-fat diet consumption. In the present study, Streptomyces microflavus was stimulated with four distinct bile acids: CA, DCA, CDCA, and UDCA. Subsequently, bacterial cells were harvested, proteins extracted, and data-independent acquisition (DIA)-based proteomic identification performed.Wed Jun 03 00:00:00 BST 2026PXD0792481919