{"database":"iProX","file_versions":[],"scores":null,"additional":{"omics_type":["Proteomics"],"submitter":["Liang Jin"],"species":["Mus Musculus"],"full_dataset_link":["http://www.iprox.org/page/project.html?id=IPX0017595000"],"submitter_email":["6238564@qq.com"],"submitter_affiliation":["China Pharmaceutical University"],"sample_protocol":[""],"repository":["iProX"],"data_protocol":[""],"additional_accession":[]},"is_claimable":false,"name":"CBX4 stabilizes NEUROD1 through SUMO-ubiquitin crosstalk to delay β-cell senescence","description":"CBX4 expression is progressively lost in aged and diabetic pancreatic β-cells, correlating with cellular senescence. Mechanistically, CBX4 stabilizes NEUROD1 by promoting its SUMOylation at lysine 38, which antagonizes NEDD4-mediated ubiquitination. Stabilized NEUROD1 enhances insulin transcription and activates CaMKII signaling by suppressing Camk2n1 expression. This cascade preserves mitochondrial function and calcium homeostasis in β-cells. Thus, the STAT5A-CBX4-NEUROD1 axis represents a key protective pathway against β-cell aging and a potential therapeutic target for T2DM.","dates":{"publication":"Thu Jun 04 00:00:00 BST 2026"},"accession":"PXD079253","cross_references":{"TAXONOMY":["10090"]}}