{"database":"iProX","file_versions":[],"scores":null,"additional":{"omics_type":["Proteomics"],"submitter":["Jianye Yang"],"species":["Rattus Norvegicus"],"full_dataset_link":["http://www.iprox.org/page/project.html?id=IPX0017820000"],"submitter_email":["jianye_yang@hust.edu.cn"],"submitter_affiliation":["Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology"],"sample_protocol":[""],"repository":["iProX"],"data_protocol":[""],"additional_accession":[]},"is_claimable":false,"name":"AQP9 Drives Myocardial Ferroptosis via TRIM25-Mediated GPX4 Ubiquitination and PI3K/AKT Suppression","description":"This proteomics dataset investigates the role of aquaporin-9 (AQP9) in regulating ferroptosis during myocardial ischemia-reperfusion (I/R) injury. Quantitative proteomic analysis of H9c2 cardiomyocytes (shNC controls vs shAQP9 knockdowns) was performed on a Bruker timsTOF, and AQP9 immunoprecipitation-mass spectrometry (IP-MS) was acquired on a Thermo Q Exactive HF. The data reveal that AQP9 drives ferroptotic cell death by promoting GPX4 degradation via TRIM25-mediated ubiquitination while simultaneously inhibiting GPX4 synthesis through the PI3K/AKT pathway, thereby dismantling antioxidant defenses in ischemic cardiomyocytes.","dates":{"publication":"Mon Jun 22 00:00:00 GMT+01:00 2026"},"accession":"PXD079978","cross_references":{"TAXONOMY":["10116"]}}