{"database":"iProX","file_versions":[],"scores":null,"additional":{"omics_type":["Proteomics"],"submitter":["Yongyong Shi"],"species":["Homo Sapiens","Hendra Virus Horse/australia/hendra/1994","Nipah Henipavirus"],"full_dataset_link":["http://www.iprox.org/page/project.html?id=IPX0017739000"],"submitter_email":["shiyongyong@gmail.com"],"submitter_affiliation":["Shanghai Jiao Tong University"],"sample_protocol":[""],"repository":["iProX"],"data_protocol":[""],"additional_accession":[]},"is_claimable":false,"name":"Protein-resolved multi-omic mapping identifies convergent host regulatory nodes in henipa-related paramyxoviruses","description":"Protein-resolved multi-omic mapping defines a comparative virus–host atlas for LayV, NiV and HeV, integrating interactomes, matched transcriptomes, quantitative proteomes and structural models across 26 viral proteins.  Henipa-related viral proteins retain substantial interaction specificity, yet converge on shared host regulatory programs, revealing host-node convergence as a conserved organizing principle across divergent paramyxoviruses.  Matrix proteins emerge as conserved host-engagement hubs that connect henipa-related viruses to two host-control axes: ABT1-linked transcriptional regulation and MRPS35-linked mitochondrial ribosome function.  M–MRPS35 engagement is conserved across multiple henipa-related viruses and is associated with progressive mitochondrial ultrastructural damage, membrane-potential collapse and loss of cellular fitness.  ABT1 chromatin profiling reveals that M proteins redirect a basal transcription-associated regulator toward altered antiviral and immune-related transcriptional pro","dates":{"publication":"Tue Jun 23 00:00:00 GMT+01:00 2026"},"accession":"PXD080026","cross_references":{"TAXONOMY":["928303","9606","121791"]}}