{"database":"iProX","file_versions":[],"scores":null,"additional":{"omics_type":["Proteomics"],"submitter":["Yunzeng Zou"],"species":["Mus Musculus"],"full_dataset_link":["http://www.iprox.org/page/project.html?id=IPX0013418000"],"submitter_email":["zou.yunzeng@zs-hospital.sh.cn"],"submitter_affiliation":["Zhongshan Hospital, Fudan University"],"sample_protocol":[""],"repository":["iProX"],"data_protocol":[""],"pubmed_abstract":["Heart failure with preserved ejection fraction (HFpEF) accounts for approximately half of all heart failure cases and predominantly affects older individuals, yet effective treatments remain limited. The molecular mechanisms linking cardiac aging to HFpEF are not fully understood. Here we show that the transcriptional regulator Sub1 is upregulated in aged hearts and in mouse models of HFpEF. Cardiac overexpression of Sub1 shortens lifespan, exacerbates diastolic dysfunction, and accelerates cardiac aging, whereas Sub1 knockdown delays cardiac aging and alleviates HFpEF features, even when initiated in aged mice. Mechanistically, Sub1 interacted with TAF9b and AROS to stabilize p53 by regulating its ubiquitination and acetylation, thereby promoting cardiomyocyte senescence. Furthermore, disrupting the Sub1-p53 interaction attenuates cardiomyocyte senescence in vitro. These findings identify Sub1 as a contributor to aging-associated HFpEF and provide insight into the molecular links between cardiac aging and disease progression."],"pubmed_title":["Sub1 contributes to heart failure with preserved ejection fraction driven by aging in mice."],"pubmed_authors":["Zhao Di D, Lin Ling L, Zhou Yufei Y, Wu Jiaying J, Xu Ran R, Li Linnan L, Zhang Xiaoxue X, Lin Hong H, Wang Jienan J, Dai Kunming K, Ding Zhiwen Z, Gao Pan P, Wu Jian J, Zou Yunzeng Y"],"additional_accession":[]},"is_claimable":false,"name":"Exploring the interaction proteins of Sub1 in aging cardiomyocytes by protein MS","description":"After transferring the Sub1 Flag plasmid into HL-1 cells, the cells were treated with bleomycin for 24 hours, followed by immunoprecipitation using Flag magnetic beads and protein mass spectrometry.","dates":{"publication":"Wed Jun 24 00:00:00 GMT+01:00 2026"},"accession":"PXD080102","cross_references":{"TAXONOMY":["10090"],"pubmed":["42402618"]}}