{"database":"iProX","file_versions":[],"scores":null,"additional":{"omics_type":["Proteomics"],"submitter":["Muqing Yang"],"species":["Homo Sapiens"],"full_dataset_link":["http://www.iprox.org/page/project.html?id=IPX0018033000"],"submitter_email":["andyymq@tongji.edu.cn"],"submitter_affiliation":["Tongji Hospital of Tongji University"],"sample_protocol":[""],"repository":["iProX"],"data_protocol":[""],"additional_accession":[]},"is_claimable":false,"name":"proteomic profiling of exosomes from specimen-derived blood in colorectal cancer","description":"Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, necessitating the discovery of novel prognostic biomarkers. Tumor-derived exosomes are emerging as rich reservoirs of protein biomarkers; however, accessing sufficient quantities of tumor-proximal material remains challenging. In this study, we introduce specimen-derived blood (sdBlood), collected immediately after surgical resection of CRC specimens, as a novel and enriched source for tumor-proximal exosome isolation. We employed label-free LC-MS/MS-based proteomics to comprehensively profile the exosomal proteome from sdBlood and compared it with matched peripheral venous blood to identify differentially enriched proteins. Our analyses revealed a distinct proteomic signature in sdBlood-derived exosomes, with several proteins showing significant prognostic potential in publicly available CRC cohorts. This project encompasses the full proteomic dataset generated from these analyses. The data provide a valuable resource for understanding the tumor microenvironment and support the potential of sdBlood as a promising liquid biopsy substrate for prognostic biomarker discovery in colorectal cancer.","dates":{"publication":"Mon Jun 29 00:00:00 GMT+01:00 2026"},"accession":"PXD080312","cross_references":{"TAXONOMY":["9606"]}}