{"database":"iProX","file_versions":[],"scores":null,"additional":{"omics_type":["Proteomics"],"submitter":["Jinmei Cheng"],"species":["Mus Musculus"],"full_dataset_link":["http://www.iprox.org/page/project.html?id=IPX0014998000"],"submitter_email":["chengjinmei@ntu.edu.cn"],"submitter_affiliation":["Nantong University"],"sample_protocol":[""],"repository":["iProX"],"data_protocol":[""],"additional_accession":[]},"is_claimable":false,"name":"Lrrc71 stabilizes septin4 to ensure sperm annulus integrity and male fertility","description":"Lrrc71 disruption resulted in male infertility involving mitochondrial sheath and sperm annulus damage. Lrrc71 could directly bind to Septin4 through its N-terminal. Mechanistically, Lrrc71 stabilizes the sperm annulus by preventing the autophagy pathway degradation of Septin4. Collectively, our findings demonstrate that Lrrc71 serves as a central hub regulating sperm motility and annulus integrity, providing insights into the pathogenic mechanisms of infertility caused by human Lrrc71 mutations.","dates":{"publication":"Mon Jun 29 00:00:00 BST 2026"},"accession":"PXD080343","cross_references":{"TAXONOMY":["10090"]}}