iProXProteomicsJinmei ChengMus Musculushttp://www.iprox.org/page/project.html?id=IPX0014998000chengjinmei@ntu.edu.cnNantong UniversityiProXfalseLrrc71 stabilizes septin4 to ensure sperm annulus integrity and male fertilityLrrc71 disruption resulted in male infertility involving mitochondrial sheath and sperm annulus damage. Lrrc71 could directly bind to Septin4 through its N-terminal. Mechanistically, Lrrc71 stabilizes the sperm annulus by preventing the autophagy pathway degradation of Septin4. Collectively, our findings demonstrate that Lrrc71 serves as a central hub regulating sperm motility and annulus integrity, providing insights into the pathogenic mechanisms of infertility caused by human Lrrc71 mutations.Mon Jun 29 00:00:00 BST 2026PXD08034310090