{"database":"iProX","file_versions":[],"scores":null,"additional":{"omics_type":["Proteomics"],"submitter":["Luping Ren"],"species":["Mus Musculus"],"full_dataset_link":["http://www.iprox.org/page/project.html?id=IPX0018124000"],"submitter_email":["renluping1122@163.com"],"submitter_affiliation":["Hebei General Hospital"],"sample_protocol":[""],"repository":["iProX"],"data_protocol":[""],"additional_accession":[]},"is_claimable":false,"name":"Dual GIP/GLP-1 receptor agonist tirzepatide ameliorates adipose tissue inflammation in high-fat, high-fructose diet-induced obese mice via the IL-17A/IL-17RA axis","description":"This study aimed to investigate the effects of the glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 dual-receptor agonist tirzepatide (TZP) on epididymal white adipose tissue (eWAT) inflammation in high-fat/high-fructose (HFHFr) diet–induced obese mice and to elucidate the underlying mechanisms. In addition, the anti-inflammatory effects of TZP were compared with those of the GLP-1 receptor agonist semaglutide (Sema).","dates":{"publication":"Thu Jul 02 00:00:00 BST 2026"},"accession":"PXD080462","cross_references":{"TAXONOMY":["10090"]}}