{"database":"iProX","file_versions":[],"scores":null,"additional":{"omics_type":["Proteomics"],"submitter":["Yong Zhang"],"species":["Homo Sapiens"],"full_dataset_link":["http://www.iprox.org/page/project.html?id=IPX0018447000"],"submitter_email":["nankai1989@foxmail.com"],"submitter_affiliation":["West China Hospital, Sichuan University"],"sample_protocol":[""],"repository":["iProX"],"data_protocol":[""],"additional_accession":[]},"is_claimable":false,"name":"Compartment-Specific B-Cell Glycosylation Remodeling Links Inflammatory Signaling to Pathogenic Fc Glycoforms in NMDAR Encephalitis","description":"our study provides an integrated multi-omics characterization of compartment-specific B-cell N-glycosylation remodeling in anti-NMDAR encephalitis. By combining CSF IgG glycoproteomics with paired single-cell transcriptomics, we identify a coordinated transcriptional reprogramming associated with inflammatory microenvironmental signaling, B-cell differentiation, and altered Fc glycan composition. Importantly, our findings support a model in which increasing antibody biosynthetic demand progressively exceeds the relative capacity for terminal glycan processing during plasma-cell activation, providing a plausible explanation for the discordance between glycosyltransferase transcription and the under-sialylated IgG phenotype observed in poor outcome groups.","dates":{"publication":"Sat Jul 18 00:00:00 GMT+01:00 2026"},"accession":"PXD081317","cross_references":{"TAXONOMY":["9606"]}}