{"database":"iProX","file_versions":[],"scores":null,"additional":{"omics_type":["Proteomics"],"submitter":["Shanling Xu"],"species":["Mus Musculus"],"full_dataset_link":["http://www.iprox.org/page/project.html?id=IPX0018735000"],"submitter_email":["xushanling@scszlyy.org.cn"],"submitter_affiliation":["Affiliated Cancer Hospital to University of Electronic Science and Technology of China"],"sample_protocol":[""],"repository":["iProX"],"data_protocol":[""],"additional_accession":[]},"is_claimable":false,"name":"Mannose-Modified Lipid Nanoparticles Loaded with siZDHHC9 Remodel the Ras-ERK Signaling Axis in Antigen-Presenting Cells to Correct Th17/Treg Imbalance and Alleviate Fusobacterium nucleatum-Driven Ulcerative Colitis","description":"Fusobacterium nucleatum-induced ulcerative colitis (UC) is characterized by persistent intestinal inflammation and an imbalance in immune homeostasis, in which abnormal activation of antigen-presenting cells (APCs) and a Th17/Treg imbalance play critical roles in disease progression. This study aimed to construct the mannose-modified lipid nanoparticles (LNPs) loaded with siZDHHC9 (Man-LNP@siZDHHC9). By integrating single-cell RNA sequencing (scRNA-seq) and multi-omics technologies, we systematically elucidated the molecular mechanisms by which Man-LNP@siZDHHC9 remodels APC-T cell interactions by inhibiting the HRas palmitoylation-mediated ERK signaling axis, thereby ameliorating Th17/Treg imbalance and alleviating Fusobacterium nucleatum-induced UC.","dates":{"publication":"Fri Jul 31 00:00:00 GMT+01:00 2026"},"accession":"PXD081963","cross_references":{"TAXONOMY":["10090"]}}