{"database":"iProX","file_versions":[],"scores":null,"additional":{"omics_type":["Proteomics"],"submitter":["Sheng Wang"],"species":["Mus Musculus"],"full_dataset_link":["http://www.iprox.org/page/project.html?id=IPX0018765000"],"submitter_email":["shengwang@tju.edu.cn"],"submitter_affiliation":["Tianjin University"],"sample_protocol":[""],"repository":["iProX"],"data_protocol":[""],"additional_accession":[]},"is_claimable":false,"name":"Proteomic profiling of senescent tumor cell membrane","description":"Senescent tumor cells exhibit intrinsically enhanced immunogenicity and can spontaneously generate tumor neoantigens. This endows their cell membrane with considerable potential as a versatile drug delivery platform and a reservoir of tumor-specific antigens for cancer immunotherapy and vaccine development. To explore the immune potential of senescent tumor cells, 4T1 breast cancer cells were subjected to a senescence inducer, doxorubicin to establish a stable senescent model. To systematically dissect the functional disparities between tumor cell membrane and senescent tumor cell membrane, label-free quantitative membrane proteomic analysis was performed on these two types of membrane vesicles.","dates":{"publication":"Mon Aug 03 00:00:00 GMT+01:00 2026"},"accession":"PXD082107","cross_references":{"TAXONOMY":["10090"]}}