{"database":"iProX","file_versions":[],"scores":null,"additional":{"omics_type":["Proteomics"],"submitter":["Shenhai Gong"],"species":["Mus Musculus"],"full_dataset_link":["http://www.iprox.org/page/project.html?id=IPX0018788000"],"submitter_email":["gsh0526@smu.edu.cn"],"submitter_affiliation":["Southern Medical University"],"sample_protocol":[""],"repository":["iProX"],"data_protocol":[""],"additional_accession":[]},"is_claimable":false,"name":"Intestinal β-galactosidase acts as a regulator of sepsis progression","description":"This project investigates the role of intestinal β-galactosidase in sepsis using 16S rRNA sequencing, metabolomic, and proteomic analyses. Septic patients showed reduced intestinal β-galactosidase activity associated with depletion of putative β-galactosidase-producing bacteria, including Blautia, Faecalibacterium, and Ruminococcus. Metabolomic profiling identified hesperetin as a key microbiota-associated metabolite, and proteomic analysis identified CDK13 as a critical downstream target regulating NLRP3 inflammasome priming and macrophage pyroptosis. Restoration of intestinal β-galactosidase promoted dietary hesperetin liberation and improved survival in septic mice.","dates":{"publication":"Wed Aug 05 00:00:00 GMT+01:00 2026"},"accession":"PXD082250","cross_references":{"TAXONOMY":["10090"]}}