{"database":"iProX","file_versions":[],"scores":null,"additional":{"omics_type":["Proteomics"],"submitter":["Qian Li"],"species":["Homo Sapiens","Mus Musculus","Burkholderia Pseudomallei K96243"],"full_dataset_link":["http://www.iprox.org/page/project.html?id=IPX0018866000"],"submitter_email":["liqianjane@tmmu.edu.cn"],"submitter_affiliation":["Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University), Chongqing, China"],"sample_protocol":[""],"repository":["iProX"],"data_protocol":[""],"additional_accession":[]},"is_claimable":false,"name":"A Burkholderia nucleomodulin hijacks the NuRD complex to epigenetically suppress efferocytosis","description":"Burkholderia pseudomallei, the facultative intracellular pathogen that causes life-threatening melioidosis, delivers virulence effectors through secretion systems to subvert host-cell immunity, yet whether it deploys nuclear-targeted effectors to reprogram host immune responses remains unclear. Here, we identify BapC as a type III secretion system nucleomodulin that suppresses macrophage efferocytosis through epigenetic reprogramming. Mechanistically, BapC enters the host nucleus through an Asp95-dependent interaction with KPNB1. Nuclear BapC engages the Nucleosome Remodeling and Deacetylase (NuRD) complex to drive histone H3K18 deacetylation and repress efferocytosis-related genes. This epigenetic suppression impairs efferocytotic clearance of apoptotic cells by macrophages and promotes bacterial survival. Pharmacological inhibition of HDAC1/2, the deacetylase subunits of NuRD, restores efferocytosis and protects against lethal infection. Together, our study reveals how B. pseudomallei exploits a bacterial nucleomodulin to hijack a host chromatin corepressor complex and suppress innate immune clearance, suggesting HDAC inhibition as a potential host-directed therapeutic strategy for melioidosis.","dates":{"publication":"Fri Aug 07 00:00:00 GMT+01:00 2026"},"accession":"PXD082311","cross_references":{"TAXONOMY":["10090","272560","9606"]}}