{"database":"iProX","file_versions":[],"scores":null,"additional":{"omics_type":["Proteomics"],"submitter":["Zhengyu  Jiang"],"species":["Homo Sapiens"],"full_dataset_link":["http://www.iprox.org/page/project.html?id=IPX0018843000"],"submitter_email":["jiangzhengyucpu@163.com"],"submitter_affiliation":["China pharmaceutical university"],"sample_protocol":[""],"repository":["iProX"],"data_protocol":[""],"additional_accession":[]},"is_claimable":false,"name":"Harnessing the E3 Ligase KLHL12 for Tumor-selective Protein Degradation via Proteolysis-targeting Chimera Technology","description":"This project harnesses the E3 ligase KLHL12 for tumor-selective protein degradation. We designed and synthesized novel PROTACs , characterized their binding affinity and selectivity by biochemical assays, and performed quantitative proteomics to systematically evaluate degradation specificity, kinetics, and anti-tumor efficacy in cancer cell models.","dates":{"publication":"Fri Aug 07 00:00:00 GMT+01:00 2026"},"accession":"PXD082322","cross_references":{"TAXONOMY":["9606"]}}