iProXProteomicsZhengyu JiangHomo Sapienshttp://www.iprox.org/page/project.html?id=IPX0018843000jiangzhengyucpu@163.comChina pharmaceutical universityiProXfalseHarnessing the E3 Ligase KLHL12 for Tumor-selective Protein Degradation via Proteolysis-targeting Chimera TechnologyThis project harnesses the E3 ligase KLHL12 for tumor-selective protein degradation. We designed and synthesized novel PROTACs , characterized their binding affinity and selectivity by biochemical assays, and performed quantitative proteomics to systematically evaluate degradation specificity, kinetics, and anti-tumor efficacy in cancer cell models.Fri Aug 07 00:00:00 GMT+01:00 2026PXD0823229606