JPOST Repositoryapplication/xmlhttps://storage.jpostdb.org/JPST000305/files/F018287.dat-pride.xml.gzhttps://storage.jpostdb.org/JPST000305/files/F018289.dat-pride.xml.gzhttps://storage.jpostdb.org/JPST000305/files/F018288.dat-pride.xml.gzhttps://storage.jpostdb.org/JPST000305/files/F018291.dat-pride.xml.gzhttps://storage.jpostdb.org/JPST000305/files/HF02_BF_P020160302003_ZXD_4_4ul_F1_R2.rawhttps://storage.jpostdb.org/JPST000305/files/HF02_BF_P020160302003_ZXD_1_4ul_F1_R2.rawhttps://storage.jpostdb.org/JPST000305/files/HF02_BF_P020160302003_ZXD_4_4ul_F1_R1.rawhttps://storage.jpostdb.org/JPST000305/files/HF02_BF_P020160302003_ZXD_3_4ul_F1_R1.rawhttps://storage.jpostdb.org/JPST000305/files/HF02_BF_P020160302003_ZXD_2_1ul_F1_R1.rawhttps://storage.jpostdb.org/JPST000305/files/HF02_BF_P020160302003_ZXD_1_4ul_F1_R1.rawhttps://storage.jpostdb.org/JPST000305/files/HF02_BF_P020160302003_ZXD_3_4ul_F1_R2.rawhttps://storage.jpostdb.org/JPST000305/files/HF02_BF_P020160302003_ZXD_2_1ul_F1_R2.rawhttps://storage.jpostdb.org/JPST000305/files/F018295.dathttps://storage.jpostdb.org/JPST000305/files/F018297.dathttps://storage.jpostdb.org/JPST000305/files/F018291.dathttps://storage.jpostdb.org/JPST000305/files/F018288.dathttps://storage.jpostdb.org/JPST000305/files/F018294.dathttps://storage.jpostdb.org/JPST000305/files/F018292.dathttps://storage.jpostdb.org/JPST000305/files/F018289.dathttps://storage.jpostdb.org/JPST000305/files/F018287.datprimaryOK200ProteomicsXiaodong ZaiBrucella Abortushttps://repository.jpostdb.org/entry/JPST000305Beijing Institute of BiotechnologyjPOSTBrucella melitensis biovar abortus., number, Brucella melitensis biovar Abortus, "Bacillus of abortion" Bang 1897, count in organism, Brucella melitensis bv. Abortus, Bacterium abortus, quantitative, presence, presence or absence in organism, proteomic analysisprojections, Maltese fever, Brucella Infections, other disease, host organism, infectious disorder, lamellae, postnatal development, Infestations and Infections, Gene, growth and development, protein, broad, protein-containing complex, process of organ, protrusion, lamella, protein polypeptide chains, diseases, polypeptide chain, resistance, Rock Fever, Gene Products, disease or disorder, diseases and disorders, Pulmonary Brucellosis, protein aggregate, Brucellosis, Brucella Infection, Pulmonary, infectious, infection, human disease, reference sample, Genomes, Vaccine., Malta Fever, proteins, ridges, Cyprus Fever, bang's disease, clinical infection, non-neoplastic, Malta fever, Infestation and Infection, papilla, Fever, disorder, Homo sapiens disease, undulant fever, Infections and Infestations, Gibraltar Fever, Cyprus fever, brucellosis, laminae, Controlled, Mediterranean fever, Gibraltar, Controlling, Cyprus, anatomical protrusion, Brucella, wide/broad, infectious diseases and manifestations, protein complex, anatomical process, Proteins, Gibraltar fever, disorders, lamina, total expressed protein, flanges, medical condition, development, Rock, native protein, natural protein, disorder due to infection, communicable disease, Protein, proteomic analysis, shelf, Infection, Pulmonary Brucelloses, condition, Brucelloses, disease by infectious agent, flange, organ process, Rock fever, growth pattern, non-developmental growth, shelves, Malta, postnatal growth, Infection and Infestation, whole genome, projection, ridge, Protein Gene Products, Gene Proteins, processes, process, disease, wide, spine, processus, infectious disease, Undulant Fever, growth, Proteomes, Undulant, transmissible diseasefalseQuantitative Proteomic Analysis of Brucella abortus under Multiple Environmental StressesWe have used a multiple-environmental-stress strategy to reveal global metabolic adaptations of B. abortus to intravacuolar environmental conditions. These conditions included: (i) a Control condition (growth on TSB, condition #1); (ii) seven single-stress conditions: (condition #2-8) and (iii) a multi-stress condition (#9). The multi-stress was a combination of each single-stress that may better simulated the environments that Brucella may occur during the infection of a host. The proteomic analysis identified and quantified in total 2,272 proteins and 74% of the theoretical proteome, which is providing a wide coverage of B. abortus genome. The identification of proteins necessary for stress resistance is crucial to elucidate the infectious process in order to control brucellosis and may provide valuable clues towards discovery of novel therapeutic targets and effective vaccines.Thu Aug 24 00:00:00 BST 2017PXD007548235