{"database":"JPOST Repository","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Mzml":["https://storage.jpostdb.org/JPST002961/files/Validation_Stool-ID_80.mzML","https://storage.jpostdb.org/JPST002961/files/Validation_Stool-ID_06.mzML","https://storage.jpostdb.org/JPST002961/files/Validation_Stool-ID_67.mzML","https://storage.jpostdb.org/JPST002961/files/Validation_Stool-ID_78.mzML","https://storage.jpostdb.org/JPST002961/files/Validation_Stool-ID_05.mzML","https://storage.jpostdb.org/JPST002961/files/Validation_Stool-ID_01.mzML","https://storage.jpostdb.org/JPST002961/files/Validation_Stool-ID_75.mzML","https://storage.jpostdb.org/JPST002961/files/Validation_Stool-ID_72.mzML","https://storage.jpostdb.org/JPST002961/files/Validation_Stool-ID_76.mzML","https://storage.jpostdb.org/JPST002961/files/Validation_Stool-ID_68.mzML","https://storage.jpostdb.org/JPST002961/files/Validation_Stool-ID_02.mzML","https://storage.jpostdb.org/JPST002961/files/Validation_Stool-ID_79.mzML","https://storage.jpostdb.org/JPST002961/files/Validation_Stool-ID_73.mzML","https://storage.jpostdb.org/JPST002961/files/Validation_Stool-ID_71.mzML","https://storage.jpostdb.org/JPST002961/files/Validation_Stool-ID_04.mzML","https://storage.jpostdb.org/JPST002961/files/Validation_Stool-ID_74.mzML","https://storage.jpostdb.org/JPST002961/files/Validation_Stool-ID_70.mzML","https://storage.jpostdb.org/JPST002961/files/Validation_Stool-ID_69.mzML","https://storage.jpostdb.org/JPST002961/files/Validation_Stool-ID_77.mzML","https://storage.jpostdb.org/JPST002961/files/Validation_Stool-ID_03.mzML"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Proteomics"],"submitter":["Eiichiro Watanabe"],"species":["Homo Sapiens (human)"],"full_dataset_link":["https://repository.jpostdb.org/entry/JPST002961"],"submitter_affiliation":["Kazusa DNA Institute"],"sample_protocol":[""],"repository":["jPOST"],"data_protocol":[""],"pubmed_abstract":["Meconium, a non-invasive biomaterial reflecting prenatal substance accumulation, could provide valuable insights into neonatal health. However, the comprehensive protein profile of meconium across gestational ages remains unclear. Here, we conducted an extensive proteomic analysis of first meconium from 259 newborns across varied gestational ages to delineate protein composition and elucidate its relevance to neonatal diseases. The first meconium samples were collected, with the majority obtained before feeding, and the mean time for the first meconium passage from the anus was 11.9 ± 9.47 h. Our analysis revealed 5370 host-derived meconium proteins, which varied depending on sex and gestational age. Specifically, meconium from preterm infants exhibited elevated concentrations of proteins associated with the extracellular matrix. Additionally, the protein profiles of meconium also exhibited unique variations depending on both specific diseases, including gastrointestinal diseases, congenital heart diseases, and maternal conditions. Furthermore, we developed a machine learning model to predict gestational ages using meconium proteins. Our model suggests that newborns with gastrointestinal diseases and congenital heart diseases may have immature gastrointestinal systems. These findings highlight the intricate relationship between clinical parameters and meconium protein composition, offering potential for a novel approach to assess neonatal gastrointestinal health."],"pubmed_title":["Host-derived protein profiles of human neonatal meconium across gestational ages."],"pubmed_authors":["Shitara Yoshihiko Y, Konno Ryo R, Yoshihara Masahito M, Kashima Kohei K, Ito Atsushi A, Mukai Takeo T, Kimoto Goh G, Kakiuchi Satsuki S, Ishikawa Masaki M, Kakihara Tomo T, Nagamatsu Takeshi T, Takahashi Naoto N, Fujishiro Jun J, Kawakami Eiryo E, Ohara Osamu O, Kawashima Yusuke Y, Watanabe Eiichiro E"],"name_synonyms":["Human, Meconiums, human being, Man (Taxonomy), Homo sapiens, determination, Modern Man, chemical analysis, Modern, total expressed protein, chemical analysis., assay, Proteomes, Man, human"],"pubmed_abstract_synonyms":["Heart, host organism, Disorders, Detrusor External Sphincter, determination, gastrointestinal disorder, Functional Gastrointestinal, Digestive system diseases NOS, protein, anal canal, [X]Other specified diseases of anus and rectum, Long Term, heart trouble, DIGESTIVE SYSTEM DIS, Infantum, Other specified disorders of rectum and anus, proctodeum, diseases, Heart Disease, symptoms, Embryologic, diseases and disorders, Disease of digestive system (disorder), Extracellular Matrices, Other gallbladder disorders NOS, protein aggregate, Transfer, Human Anal Gland, Effect, Embryologic Ages, average, human disease, disease of digestive system, Sex, Machine, Phenotypic, External Anal Sphincters, Sphincters, sex, Internal Anal, Fetal, anal opening, gastroenteropathy, Homo sapiens disease, Long-Term Effects, Other intestinal disorders NOS (disorder), Normalcies., NEWBORN (0-27 DAYS), Heart Disorder, Meconiums, screening, anal orifice, OTHER DISEASES OF INTESTINES AND PERITONEUM, Other disorders of intestine, inborn, gastroenterological system disease, cloaca, gastrointestinal disease, Cardiac Disorder, Learning, Longterm Effect, Other diseases of the intestines and peritoneum (disorder), Normalcy, gastrointestinal system disorder, heart disorder, gastroenterological system disorder, Digestive System Diseases, Diseases, Gastrointestinal Diseases, NOS, disease or disorder of digestive system, Individual, Functional digestive disorders, External, alimentary system disease, Cholera Infantum, Genotypic, Other diseases of the intestines and peritoneum, Disease of digestive system, heart/pericardial trouble, Neonatal Disease, [X]Other diseases of the digestive system, System Diseases, signs, System Disease, Chronologic Fetal Maturity, Gastrointestinal Disorder, Anal Sphincter, Age, disease, Health, Fetal Maturity, Neonatal Diseases, opening of terminal part of digestive tract, Anatomical anal canal, digestive system disease or disorder, heart disease or disorder, heart/pericardial disease, Cholera, Functional Gastrointestinal Disorders, other disease, disorder of heart/pericardium, Internal, Cardiac Diseases, Effects, Gastrointestinal, Matrix, connatal, Gene, Heart Diseases, protein-containing complex, Matrices, Normalcies, Other disorders of intestine (disorder), Cardiac Disease, Human, disease of heart, Functional Gastrointestinal Disorder, Detrusor External Sphincters, Gastrointestinal and digestive disorder, Cardiac, Anal, disease or disorder of heart, Other gallbladder disorders NOS (disorder), heart/pericardial disorder, Other gallbladder disorders (disorder), Gene Products, Functional, disease or disorder, Chronologic, intestinal disease, Embryologic Age, Maturity, Disorder of digestive system (disorder), Normalities, gastrointestinal system disease, Transfer Learning, matrisome, Genotypic Sex, Gastrointestinal Disorders, Longterm, anal pad, Other intestine disorders, digestive disease, heart/pericardial disease or disorder, Human Anal Glands, [X]Other diseases of intestines, Internal Anal Sphincters, Long-Term, disorder of heart, disorder of digestive system, non-neoplastic, stomach or intestinal disorder, CARDIAC DIS, Internal Anal Sphincter, digestive system disease, Sphincter, Ages, Extracellular, Disorder, disorder, Long-Term Effect, Anal Glands, Gestational, HEART DIS, Fetal Age, intestinal diseases, canalis analis, Anal Sphincters, pars analis recti, Digestive, Neonatal, Individual Health, Disease, Gastrointestinal Disease, findings, Infants, protein complex, Other disorders of gallbladder, not elsewhere classified, Proteins, disorders, medical condition, External Anal, Digestive System, Cardiac Disorders, Disorder of digestive system, digestive system disorder, DISEASES OF THE DIGESTIVE SYSTEM, GIT diseases, anus, native protein, Chronologic Fetal, Protein, Long Term Effects, chemical analysis, proteomic analysis, cloacal chamber, Other intestinal disorders NOS, OTHER DISEASES OF DIGESTIVE SYSTEM, Fetal Ages, condition, GASTROINTESTINAL DIS, Anus, Heart Disorders, git disease, underdeveloped, Normality, Digestive system diseases NOS (disorder), [X]Other diseases of the digestive system (disorder), [X]Other specified diseases of anus and rectum (disorder), heart disease, Other gallbladder disorders, Longterm Effects, Protein Gene Products, RECTAL & ANAL DIS NEC, Detrusor External, Gene Proteins, cardiac disease, Phenotypic Sex, POSTOP GI FUNCT DIS NEC, [X]Other diseases of intestines (disorder), External Anal Sphincter, Newborn, mesenteron, assay, Anal canal viewed anatomically, Anal Gland, Gestational Ages"],"pubmed_title_synonyms":["Protein Gene Products, Human, Meconiums., NEWBORN (0-27 DAYS), Gene Proteins, Neonatal, host organism, human being, native protein, Man (Taxonomy), Homo sapiens, protein complex, Modern Man, Protein, Modern, Gene Products, Proteins, Newborn, Gene, protein, protein aggregate, protein-containing complex, Man, human"],"description_synonyms":["Protein Gene Products, Meconiums, Gene Proteins, Neonatal, Disease, native protein, Neonatal Disease, protein complex, Protein, proteomic analysis, causality, Diseases, Gene Products, Proteins, Neonatal Diseases., pathogenesis, Gene, protein, causes, protein aggregate, protein-containing complex"],"additional_accession":[]},"is_claimable":false,"name":"Deep proteome analysis of initial meconium from human neonates for validation analysis","description":"This project includes additional data of JPST002405. We conducted a deep proteomic analysis of meconium in 79 newborns to establish a meconium protein profile and gain insights into the underlying causes of neonatal diseases.","dates":{"publication":"Thu May 30 00:00:00 BST 2024"},"accession":"PXD050164","cross_references":{"TAXONOMY":["9606"],"pubmed":["39019879"]}}