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preventive measures, dimetil sulfoxido, Cerebral Hemispheres, Rimso, Dimethylsulphinyl, (indol-3-yl)acetic acid, Dimethylsulfoxide, HEL-S-284, PTBR, Sensitivity, HIGM2, Bladder pain syndrome, Intraperitoneal Injection, Dimethylsulfoxid, Heterologous, Controlled, nucleus amygdaloideus medialis, sulfinylbis-, Controlling, DMSO, Degradations, preventive therapy, suprasegmental structures, BZRP, dimethyli sulfoxidum, DBI, dmso, methylsulfinylmethane, mouse, nucleus medialis amygdalae, medial amygdalar nucleus, Right Cerebral Hemisphere, Protein Digestion, Digestions, encephalon, PBS, Human Donor, PBR, Cerebral Hemisphere, special AT-rich sequence-binding protein 1, (CH3)2SO, Thymocyte, (Indol-3-yl)acetate, Proteolyses, PKBS, Mus, Dimexide, Digestion, body system., Cerebra, Dimethylsulphoxide, Protein, Mini-ICE, chemical analysis, Heterologous Insemination, Donor, IES, connected anatomical system, eagle-Barrett syndrome, Sulfoxide, Sulfinylbis(methane), Communicating branch of phrenic nerve to internal thoracic plexus, Rimso 50, Artificial, AW413156, Mus musculus, pheromone catabolic process, absence of, SATB1, Painful Bladder Syndrome, with urinary tract Abnormality and cryptorchidism, Caspase-14 subunit p10, Arp2, Rimso50, ARP2, mice, prophylaxis, Protein Digestions, Intraperitoneal, Swiss Mouse, Specificity, 3-Indolylessigsaeure, dimethyl sulfoxide, Sclerosol, Dimethyl Sulphoxide, House Mice, Caspase-14 subunit p19, mDRC, MICE, hemisphere, Laboratory Mice, domesticus, organ system, Artificial Insemination, multicellular organismal protein catabolic process, heteroauxin, Painful bladder syndrome, Specificity and Sensitivity, control, hemispherium cerebri, Mouse, assay, dimethyl sulfur oxide, endbrain, 2610306G12Rik, Laboratory Mouse, Bladder Pain Syndrome"],"additional_accession":[]},"is_claimable":false,"name":"Degron-based targeted protein degradation systems in mice","description":"To investigate the specificity of protein degradation and identify potential neo-substrates for the OsTIR1-AID2 and hCRBN-S4D systems, we conducted proteomics analyses of thymocytes 16 hours after intraperitoneal injection of 5-Ph-IAA or PBS in Rosa26OsTIR1/+;Satb1V-AID/V-AID and Rosa26OsTIR1/+;Satb1 +/+ mice, as well as POM or DMSO in Rosa26hCRBN/+;Satb1V-S4D/V-S4D and Rosa26hCRBN/+;Satb1+/+ mice, alongside with wildtype control mice. Furthermore, we conducted proteomics analysis in the cerebrum of DMSO- and POM-treated Rosa26hCRBN/+;Satb1+/+ mice to identify neo-substrates in the brain for the hCRBN-S4D system. \n\n","dates":{"publication":"Fri Oct 25 00:00:00 GMT+01:00 2024"},"accession":"PXD050563","cross_references":{"TAXONOMY":["10090"]}}