JPOST Repositoryapplication/xmlhttps://storage.jpostdb.org/JPST003402/files/Figure%20S2C,%20S4C.%20Analysis%20of%20additional%20ERMCS%20interactors%20of%20wild-type%20and%20mutant%20TMX2..xlsxhttps://storage.jpostdb.org/JPST003402/files/Figure%206A-C,%20S7A.%20Alterations%20in%20the%20mitochondrial%20proteome%20in%20the%20absence%20of%20TMX2..xlsxhttps://storage.jpostdb.org/JPST003402/files/Figure%203C.%20Characterization%20of%20TOM70%20cysteine%20sulfenylation%20site..xlsxhttps://storage.jpostdb.org/JPST003402/files/Figure%202A,%20S2A.%20TMX2%20interacts%20with%20outer%20mitochondrial%20membrane%20(OMM)%20proteins..xlsxhttps://storage.jpostdb.org/JPST003402/files/Figure%205A-C,%20S6A.%20TMX2%20regulates%20cellular%20lipidomics..xlsxhttps://storage.jpostdb.org/JPST003402/files/Figure%20S5A-B.%20MAM%20proteome%20of%20wild-type%20and%20TMX2-KO%20cells..xlsxhttps://storage.jpostdb.org/JPST003402/files/Figure%206E.%20Assessing%20the%20correlation%20between%20the%20altered%20TOM70%20interactomes%20under%20TMX2%20depletion%20and%20TOM70%20importome..xlsxhttps://storage.jpostdb.org/JPST003402/files/Figure%205A-C,%20S6A.%20Lipidomic%20Profiling%20Analysis%20Report.pdfhttps://storage.jpostdb.org/JPST003402/files/Figure%20S2C,%20S4C.%20Analysis%20of%20additional%20ERMCS%20interactors%20of%20wild-type%20and%20mutant%20TMX2..ziphttps://storage.jpostdb.org/JPST003402/files/Figure%205A-C,%20S6A.%20TMX2%20regulates%20cellular%20lipidomics..ziphttps://storage.jpostdb.org/JPST003402/files/Figure%206A-C,%20S7A.%20Alterations%20in%20the%20mitochondrial%20proteome%20in%20the%20absence%20of%20TMX2..ziphttps://storage.jpostdb.org/JPST003402/files/Figure%206E.%20Assessing%20the%20correlation%20between%20the%20altered%20TOM70%20interactomes%20under%20TMX2%20depletion%20and%20TOM70%20importome..ziphttps://storage.jpostdb.org/JPST003402/files/Figure%202A,%20S2A.%20TMX2%20interacts%20with%20outer%20mitochondrial%20membrane%20(OMM)%20proteins..ziphttps://storage.jpostdb.org/JPST003402/files/Figure%20S5A-B.%20MAM%20proteome%20of%20wild-type%20and%20TMX2-KO%20cells..ziphttps://storage.jpostdb.org/JPST003402/files/Figure%206E.%20Assessing%20the%20correlation%20between%20the%20altered%20TOM70%20interactomes%20under%20TMX2%20depletion%20and%20TOM70%20importome.pyhttps://storage.jpostdb.org/JPST003402/files/Figure%203C.%20Characterization%20of%20TOM70%20cysteine%20sulfenylation%20site..zipprimaryOK200ProteomicsThomas SimmenHomo Sapiens (human)https://repository.jpostdb.org/entry/JPST003402University of AlbertajPOSTfalseThe ER Thioredoxin-Related Transmembrane Protein TMX2 Controls Redox-Mediated Tethering of ER-Mitochondria Contacts (ERMCS)Our study demonstrates that ERMCS-localized TMX2 enhances the antioxidant activity of PRDX1/2 on TOM70, thereby preventing sulfenylation of TOM70 at C206 and regulating mitochondrial metabolism.Fri Oct 31 00:00:00 GMT 2025PXD0573809606