{"database":"JPOST 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Neto"],"species":["Danio Rerio"],"full_dataset_link":["https://repository.jpostdb.org/entry/JPST003624"],"submitter_affiliation":["Butantan Institute"],"sample_protocol":[""],"repository":["jPOST"],"data_protocol":[""],"description_synonyms":["biochemical pathways, l(3)rK137, protein translation, Metabolic Process, Lattices, Microtrabecular, MPP, Mpp, Processes, Cytoplasmic Filaments, CMT1B, number, Metabolic Concepts, MPP-6, Gene, Spectrum Analyses, Metabolic Processes, 0763/13, CG17228, alpha-mitochondrial processing peptidase, Myelin peripheral protein, presence, l(3)10419, 1135/09, 1135/07, peptide, dmTAF8, Polypeptides, Filament, DmelCG17228, peptido, Cytoskeletons, Roles, Metabolism, HL-VIII, Cytoskeletal Filaments, 0451/09, Mass, Gene Products, Concepts, anon-WO0140519.15, matrix processing peptidase, F15E12.6, P-zero, Neural Protection, Prosp, Analysis, Metabolism Concept, Phenomenon, Metabolism Phenomena, Microtrabecular Lattice, Mass Spectroscopy, Neural, Mass Spectrum Analysis, PROS, F15E12_6, 0244/09, 0585/13, peptides, Cytoplasmic Filament, Neuronal Protection, Analyses, MUB3_18, catabolism, CMTDID, Cytoskeletal, DROPROSA, 0671/02., CG7128, Metabolic Concept, metabolic process resulting in cell growth, CMT1, MUB3.18, l(3)j6E2, CMTDI3, l(3)rH013, Cytoplasmic, 671/2, prod, 0320/10, Prodos, DMPROSPER, Microtrabecular Lattices, Neuronal, Role Concepts, biotransformation, Neuron, peptidos, toxic potential, TAF, 0563/18, HMSNIB, Catabolism, 0671/02, matrix peptidase, l(3)j12C8, protein anabolism, protein biosynthetic process, CHM, l(3)rO534, processing enhancing peptidase (for one of two subunits), degradation, Process, PRO, Pro, metabolism resulting in cell growth, Proteins, CYS, Spectrum Analysis, Protection, Peptide, l(3)rJ806, Pros, Myelin protein zero, Concept, Metabolic Phenomena, mitochondrial protein precursor-processing proteinase activity, Spectroscopy, polypeptide, Metabolism Concepts, l(3)rL433, count in organism, DSS, PROS-1, MS, PROS-2, hemopoietic progenitor cell, Role Concept, l(3)rI160, 0441/16, pro, 1316/02, Protein, proteomic analysis, Phenomena, margin of safety, Cytoskeletal Filament, protein formation, Role, TFIID, BcDNA:HL08040, protein biosynthesis, secretion, beta-mitochondrial processing peptidase, and GLY protein 2, metabolism, Mass Spectrum Analyses, ATCMPG1, MET, ATCMPG2, Metabolic Phenomenon, Mass Spectrum, multicellular organism metabolic process, and GLY protein 1, processing enhancing peptidase activity, biodegradation, Voila, Metabolic, 0664/07, 1167/13, Spectrometry, CMT2I, Filaments, CMT2J, TAF[[II]], Neuron Protection, l(3)rK204, P0, Protein Gene Products, Gene Proteins, DmelCG7128, protein synthesis, label, MPP6, Lattice, CMT4E, Peptid, l(1)16Fg, Polypeptide, matrix processing proteinase, neuroprotection, TAF8, 0989/01, pds, Anabolism"],"name_synonyms":["zebra fish, leopard danio, Zebra Fish, (-)-(S)-proline, prolina, L-alpha-pyrrolidinecarboxylic acid, DL-Proline, Prolin, Protection, zebra danio, Danio rerio frankei, pyrrolidine-2-carboxylic acid, L-Proline, CG9063, proline, Brachydanio rerio, Neural Protection, Cyprinus rerio, D. rerios, Neural, Zebra, (-)-2-pyrrolidinecarboxylic acid, Hpro, Danio rerio, L-Prolin, Neuronal Protection, prolinum, Danio frankei, Zebrafishes, BcDNAGH03694, P, 2-Pyrrolidinecarboxylic acid, Oligopeptide, Fishes, (-)-proline, danio, Brachydanio rerio frankei., (S)-pyrrolidine-2-carboxylic acid, BcDNA:GH03694, Zebra danios, (2S)-pyrrolidine-2-carboxylic acid, PROLINE, 3L6, Neuron Protection, (S)-2-pyrrolidinecarboxylic acid, Zebra danio, rich, Neuronal, B. rerio, L Proline, Zebra Fishes, D. rerio, Neuron, (S)-2-carboxypyrrolidine, neuroprotection, L-(-)-proline, L-pyrrolidine-2-carboxylic acid, zebrafish, DmelCG9063"],"additional_accession":[]},"is_claimable":false,"name":"Proteomic Mapping of Proline-rich oligopeptide 7a Induced Neuroprotection in a Zebrafish Parkinson’s Model","description":"The neuroprotection mediated by the PRO-7a (<EDGPIPP) peptide against MPP(+)-induced toxicity was analyzed using label-free quantitative mass spectrometry. Proteomic analysis revealed the restoration of 27 proteins associated with cellular stress, metabolism, cytoskeleton, and protein synthesis, suggesting a modulatory role of PRO-7a in maintaining neuronal viability.","dates":{"publication":"Tue Feb 25 00:00:00 GMT 2025"},"accession":"PXD061139","cross_references":{"TAXONOMY":["7955"]}}