{"database":"JPOST Repository","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Tabular":["https://storage.jpostdb.org/JPST003748/files/report.pg_matrix.tsv"],"Txt":["https://storage.jpostdb.org/JPST003748/files/report.log.txt"],"Raw":["https://storage.jpostdb.org/JPST003748/files/SP_CisR3.raw","https://storage.jpostdb.org/JPST003748/files/SP_CisR2.raw","https://storage.jpostdb.org/JPST003748/files/SP_CisR1.raw","https://storage.jpostdb.org/JPST003748/files/SP_QCpool1.raw","https://storage.jpostdb.org/JPST003748/files/SP_QCpool2.raw","https://storage.jpostdb.org/JPST003748/files/SP_CisS1.raw","https://storage.jpostdb.org/JPST003748/files/SP_CisS2.raw","https://storage.jpostdb.org/JPST003748/files/SP_CisS3.raw"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Proteomics"],"submitter":["Prof. Sanjeeva Srivastava"],"species":["Homo Sapiens (human)"],"full_dataset_link":["https://repository.jpostdb.org/entry/JPST003748"],"submitter_affiliation":["IIT Bombay"],"sample_protocol":[""],"repository":["jPOST"],"data_protocol":[""],"additional_accession":[]},"is_claimable":false,"name":"Proteomic Profiling of Cisplatin-Resistant and Sensitive MDA-MB-231 Triple-Negative Breast Cancer Cell Lines","description":"This dataset includes mass spectrometry-based proteomic profiles of cisplatin-resistant (cisR) and cisplatin-sensitive (cisS) MDA-MB-231 triple-negative breast cancer (TNBC) cell lines. The study aimed to investigate the molecular alterations contributing to cisplatin resistance using data-independent acquisition (DIA) proteomics. Key findings revealed upregulation of extracellular matrix (ECM) remodeling proteins (e.g., COL6A1, COL6A3), drug efflux transporters (e.g., ABCC4), and membrane-associated resistance proteins (e.g., TIMP1, MMP-14, APP), highlighting their potential roles in chemoresistance. The data provide insights into resistance-associated signaling, metabolic pathways, and potential therapeutic targets in TNBC.","dates":{"publication":"Tue Apr 07 00:00:00 BST 2026"},"accession":"PXD062652","cross_references":{"TAXONOMY":["9606"]}}